Gerbitz, Armin and Ewing, Patricia and Wilke, Andrea and Schubert, Thomas and Eissner, Guenther and Dietl, Barbara and Andreesen, Reinhard and Cooke, Kenneth R. and Holler, Ernst (2004) Induction of heme oxygenase-1 before conditioning results in improved survival and reduced graft-versus-host disease after experimental allogeneic bone marrow transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 10 (7). pp. 461-472. ISSN 1083-8791,
Full text not available from this repository. (Request a copy)Abstract
Acute graft-versus-host disease (aGVHD) remains one of the main obstacles after allogeneic bone marrow transplantation (BMT). Using a well-established mouse BMT model in which aGVHD is induced across a haploidentical mismatch, we show that the expression of heme oxygenase-1 (HO-1) can be induced by cobalt-protoporphyrin IX (CoPP) in aGVHD target organs such as liver and bowel and that the induction of HO-1 before BMT results in improved overall survival and reduced aGVHD. Serum levels of proinflammatory cytokines were markedly reduced in CoPP-treated animals. Recipients displayed less damage to the intestinal mucosa, and this resulted in reduced serum lipopolysaccharide levels at day 6 after transplantation. Peritoneal cells and CD45(+) liver cells isolated from mice that received transplants strongly expressed HO-1 and displayed a reduction in the expression of activation markers such as CD11b, CD80, and major histocompatibility complex class I. This resulted in reduced T-cell activation ex vivo. These results demonstrate that the induction of HO-1 before high-dose conditioning protects the host in multiple ways and effectively ameliorates aGVHD. (C) 2004 American Society for Blood and Marrow Transplantationy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; T-REGULATORY-CELLS/; CYTOKINE DYSREGULATION; IL-10 PRODUCTION; LUNG INJURY; MICE; INTERLEUKIN-10; COMPLICATIONS; EXPRESSION; MODULATION; GVHD e; cytokines; heme oxygenase; BMT; LPS; protoporphyrin; CoPP |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2021 08:21 |
| Last Modified: | 07 Jul 2021 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37467 |
Actions (login required)
 |
View Item |
