Garcia-Sanchez, J. and Rouland, J.-F. and Spiegel, D. and Pajic, B. and Cunliffe, I. and Traverso, C. and Landry, J. (2004) A comparison of the fixed combination of latanoprost and timolol with the unfixed combination of brimonidine and timolol in patients with elevated intraocular pressure. A six month, evaluator masked, multicentre study in Europe. BRITISH JOURNAL OF OPHTHALMOLOGY, 88 (7). pp. 877-883. ISSN 0007-1161, 1468-2079
Full text not available from this repository. (Request a copy)Abstract
Purpose: To compare the intraocular pressure (IOP) reducing effect and safety of fixed combination (FC) latanoprost/timolol with unfixed combination (UFC) brimonidine/timolol in patients with increased IOP. Methods: In this 6 month, randomised, evaluator masked, parallel group European study, patients with glaucoma or ocular hypertension and IOP greater than or equal to21 mm Hg on monotherapy or >16 mm Hg on dual therapy received either FC latanoprost/timolol at 8:00AM or UFC brimonidine/timolol at 8: 00AM and 8:00PM. The primary outcome was the difference from baseline to month 6 in mean diurnal IOP reduction. Results: 325 of 334 randomised patients were included in intent to treat analyses (FC latanoprost/timolol, 163; UFC brimonidine/timolol, 162). Baseline diurnal IOP levels were similar: FC latanoprost/timolol, 26.4 (SD 2.7) mm Hg; UFC brimonidine/timolol, 26.5 (SD 2.8) mm Hg (p = 0.851). At month 6, levels were 16.9 (SD 2.8) mm Hg in FC latanoprost/timolol patients and 18.2 (SD 3.1) mm Hg in UFC brimonidine/timolol patients (p < 0.001). No adverse events were reported by 76.4% and 75.5% of patients receiving FC latanoprost/timolol versus UFC brimonidine/timolol, respectively. Larger proportions of brimonidine/timolol treated patients reported study medication related adverse events (18.6% v 7.3%) and discontinued study participation because of this (10.8% v 1.8%). Conclusion: Fixed combination latanoprost/timolol administered once daily is both more effective and better tolerated than twice daily dosing with UFC brimonidine/timolol.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPEN-ANGLE GLAUCOMA; AQUEOUS-HUMOR DYNAMICS; OCULAR HYPERTENSION; RANDOMIZED-TRIAL; HUMAN EYES; PROSTAGLANDIN-F2-ALPHA ANALOG; ADJUNCTIVE THERAPY; 0.2-PERCENT; EFFICACY; DORZOLAMIDE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2021 08:29 |
| Last Modified: | 07 Jul 2021 08:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37469 |
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