von Loewenich, Friederike D. and Scorpio, Diana G. and Reischl, Udo and Dumler, J. Stephen and Bogdan, Christian (2004) Control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88. EUROPEAN JOURNAL OF IMMUNOLOGY, 34 (7). pp. 1789-1797. ISSN 0014-2980, 1521-4141
Full text not available from this repository. (Request a copy)Abstract
Anaplasma phagocytophilum is an obligate intracellular bacterium that is related to rickettsial organisms and replicates in the hostile environment of neutrophils. Previous studies with SCID mice suggested that T and/or B cells are required for its control in vivo. Here, we used mice deficient for Toll-like receptor (TLR)2 and TLR4, MyD88, tumor necrosis factor, inducible nitric oxide synthase, or phagocyte NADPH oxidase (gp91(phox-/-)) to define the pathways that are critical for the recognition and the killing of this pathogen. Whereas SCID mice developed a 60-fold higher bacterial load in the blood compared to wild-type mice and succumbed to infection, all other gene-deficient mouse strains were fully capable in overcoming a systemic infection with A. phagocytophilum. From these data we conclude that effector mechanisms that are crucial to the defense against numerous other intracellular pathogens are dispensable for the control of A. phagocytophilum.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN GRANULOCYTIC EHRLICHIOSIS; MURINE MODEL; LEISHMANIA-MAJOR; CUTTING EDGE; MYD88-DEFICIENT MICE; HUMAN NEUTROPHILS; GAMMA-INTERFERON; AGENT; INFECTION; SUSCEPTIBILITY; Anaplasma phagocytophilum; inducible nitric oxide synthase; phagocyte NADPH oxidase; tumor necrosis factor; MyD88 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jul 2021 09:26 |
| Last Modified: | 07 Jul 2021 09:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37479 |
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