Gerbitz, Armin and Schultz, Michael and Wilke, Andrea and Linde, Hans-Joerg and Schoelmerich, Juergen and Andreesen, Rainer and Holler, Ernst (2004) Probiotic effects on experimental graft-versus-host disease: let them eat yogurt. BLOOD, 103 (11). pp. 4365-4367. ISSN 0006-4971,
Full text not available from this repository. (Request a copy)Abstract
Acute graft-versus-host disease (aGVHD) often limits feasibility and outcome of allogeneic bone marrow transplantation. Current pathophysiologic concepts of aGVHD involve conditioning regimens, donor-derived T cells, proinflammatory cytokines, and bacterial lipopolysaccharide (LIPS) as a major trigger for aGVHD. LIPS derives mostly from gram-negative bacteria and can enter circulation through the impaired mucosal barrier after the conditioning regimen. Probiotic microorganisms have been shown to alter the composition of the intestinal microflora and thereby mediate anti-inflammatory effects. We hypothesized that modifying the enteric flora using the probiotic microorganism Lactobacillus rhamnosus GG, would ameliorate aGVHD. Here we show that oral administration of Lactobacillus rhamnosus GG before and after transplantation results in improved survival and reduced aGVHD. Furthermore, subculturing of mesenteric lymph node tissue revealed a reduced translocation of enteric bacteria. Our findings suggest that alteration of the intestinal microflora plays an important role in the initiation of experimental aGVHD. (C) 2004 by The American Society of Hematology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; RADIATION CHIMERAS; SECONDARY DISEASE; MICROFLORA; CYTOKINES; ENDOTOXIN; BACTERIA; LESIONS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jul 2021 05:37 |
| Last Modified: | 14 Jul 2021 05:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37560 |
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