Buechler, Christa and Bodzioch, Marek and Bared, Salim Maa and Sigruener, Alexander and Boettcher, Alfred and Lapicka-Bodzioch, Katarzyna and Aslanidis, Charalampos and Duong, Chinh Quoc and Grandl, Margot and Langmann, Thomas and Dembinska-Kiec, Aldona and Schmitz, Gerd (2004) Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1. GENOMICS, 83 (6). pp. 1116-1124. ISSN 0888-7543,
Full text not available from this repository. (Request a copy)Abstract
The highly homologous genes NIPSNAP3 and NIPSNAP4, with 87% amino acid identity, are members of the NIPSNAP family with putative roles in vesicular trafficking. NIPSNAP3 mRNA and NIPSNAP4 mRNA and protein were detected in multiple tissues and cells at varying degrees. Interestingly, NIPSNAP3 is most highly expressed in skeletal muscle, where NIPSNAP4 has a low rnRNA abundance. NIPSNAP4 was found associated with membranes and partly localized in rafts. The ubiquitous expression of the highly conserved NIPSNAPs and their association with membranes further support an important cellular function of these proteins probably linked to vesicular trafficking. The NIPSNAP3 and NIPSNAP4 genes are located in close proximity to the 3' end of the ATP-binding cassette transporter A1 (ABCA1), whose mutations cause familial high-density lipoprotein deficiency syndromes. The adjacent genomic location and the finding that ABCA1 is a regulator of vesicular trafficking may indicate a functional relation of these proteins, even though NIPSNAP4 does not interact directly with ABCA1 nor is its expression altered in cells with mutated ABCA1. (C) 2004 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TANGIER-DISEASE; VESICULAR TRANSPORT; MUTATIONS; EFFLUX; NIPSNAP; ATP-binding cassette transporter A1; intracellular vesicles; plasma membrane; raft; TaqMan; tissue expression; Tangier disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Jul 2021 15:14 |
| Last Modified: | 14 Jul 2021 15:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37578 |
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