Kariminia, Amina and Holtan, Shernan G. and Ivison, Sabine and Rozmus, Jacob and Hebert, Marie-Josee and Martin, Paul J. and Lee, Stephanie J. and Wolff, Daniel and Subrt, Peter and Abdossamadi, Sayeh and Sung, Susanna and Storek, Jan and Levings, Megan and Aljurf, Mahmoud and Arora, Mukta and Cutler, Corey and Gallagher, Genevieve and Kuruvilla, John and Lipton, Jeff and Nevill, Thomas J. and Newell, Laura F. and Panzarella, Tony and Pidala, Joseph and Popradi, Gizelle and Szwajcer, David and Tay, Jason and Toze, Cynthia L. and Walker, Irwin and Couban, Stephen and Storer, Barry E. and Schultz, Kirk R. (2016) Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3(+) NK cells. BLOOD, 127 (24). pp. 3082-3091. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
Chronic graft-versus-host disease(cGVHD) remains one of the most significant long-term complications after allogeneic blood and marrow transplantation. Diagnostic biomarkers for cGVHD are needed for early diagnosis and may guide identification of prognostic markers. No cGVHD biomarker has yet been validated for use in clinical practice. We evaluated both previously known markers and performed discovery-based analysis for cGVHD biomarkers in a 2 independent test sets (total of 36 cases <= 1 month from diagnosis and 31 time-matched controls with no cGVHD). On the basis of these results, 11 markers were selected and evaluated in 2 independent replication cohorts (total of 134 cGVHD cases and 154 controls). cGVHD cases and controls were evaluated for several clinical covariates, and their impact on biomarkers was identified by univariate analysis. The 2 replications sets were relatively disparate in the biomarkers they replicated. Only sBAFF and, most consistently, CXCL10 were identified as significant in both replication sets. Other markers identified as significant in only 1 replication set included intercellular adhesion molecule 1 (ICAM-1), anti-LG3, aminopeptidase N, CXCL9, endothelin-1, and gelsolin. Multivariate analysis found that all covariates evaluated affected interpretation of the biomarkers. CXCL10 had an increased significance in combination with anti-LG3 and CXCL9, or inversely with CXCR3(+)CD56(bright) natural killer (NK) cells. There was significant heterogeneity of cGVHD biomarkers in a large comprehensive evaluation of cGVHD biomarkers impacted by several covariates. Only CXCL10 strongly correlated in both replication sets. Future analyses for plasma cGVHD biomarkers will need to be performed on very large patient groups with consideration of multiple covariates.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONSENSUS DEVELOPMENT PROJECT; WORKING GROUP-REPORT; CHRONIC GVHD; T-CELLS; CLINICAL-TRIALS; TRANSPLANTATION; IMPACT; PATHOGENESIS; DIAGNOSIS; SURVIVAL; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Transplantationszentrum |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2019 12:53 |
| Last Modified: | 20 Mar 2019 12:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3761 |
Actions (login required)
 |
View Item |
