Botella, Jose A. and Ulschmid, Julia K. and Gruenewald, Christoph and Moehle, Christoph and Kretzschmar, Doris and Becker, Katja and Schneuwly, Stephan (2004) The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration. CURRENT BIOLOGY, 14 (9). pp. 782-786. ISSN 0960-9822, 1879-0445
Full text not available from this repository. (Request a copy)Abstract
A growing body of evidence suggests that oxidative stress is a common underlying mechanism in the pathogenesis of neurodegenerative disorders such as Alzheimer's, Huntington's, Creutzfeld-Jakob and Parkinson's diseases [1-4]. Despite the increasing number of reports finding a causal relation between oxidative stress and neurodegeneration, little is known about the genetic elements that confer protection against the deleterious effects of oxidation in neurons. We have isolated and characterized the Drosophila melanogaster gene sniffer, whose function is essential for preventing age-related neurodegeneration. In addition, we demonstrate that oxidative stress is a direct cause of neurodegeneration in the Drosophila central nervous system and that reduction of sniffer activity leads to neuronal cell death. The overexpression of the gene confers neuronal protection against oxygen-induced apoptosis, increases resistance of flies to experimental normobaric hyperoxia, and improves general locomotor fitness. Sniffer belongs to the family of short-chain dehydrogenase/reductase (SDR) enzymes and exhibits carbonyl reductase activity. This is the first in vivo evidence of the direct and important implication of this enzyme as a neuroprotective agent in the cellular defense mechanisms against oxidative stress.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GLUTATHIONE-REDUCTASE; SUPEROXIDE-DISMUTASE; MELANOGASTER; DISEASE; OVEREXPRESSION; DISORDERS; PROTEINS; PATHWAYS; SYSTEM; DAMAGE; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jul 2021 08:16 |
| Last Modified: | 20 Jul 2021 08:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37647 |
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