Knoell, Antje and Boehm, S. and Hahn, J. and Holler, E. and Jilg, W. (2004) Reactivation of resolved hepatitis B virus infection after allogeneic haematopoietic stem cell transplantation. BONE MARROW TRANSPLANTATION, 33 (9). pp. 925-929. ISSN 0268-3369
Full text not available from this repository. (Request a copy)Abstract
Hepatitis B virus (HBV) reactivation after allogeneic haematopoietic stem cell transplantation (allo-HSCT) is well known in HBsAg-positive carriers but has only occasionally been reported in patients with resolved HBV infection. We investigated six allo-HSCT recipients with pretransplant anti-HBs and anti-HBc antibodies for serologic markers of HBV infection and for the presence of HBV-DNA in serum. Reverse seroconversion, that is, reappearance of HBsAg after a gradual loss of anti-HBs, but no severe liver damage was observed in three patients at 14, 22 and 12 months after HSCT, respectively. There was an increase in HBV-DNA concentration prior to reverse seroconversion. One patient was repeatedly HBV-DNA positive (10(2) - 10(3) copies/ml) without reverse seroconversion. Sequencing of the HBsAg and precore region derived from the four HBV-DNA-positive patients showed no relevant mutations. In conclusion, this study demonstrated a high risk (50%) of reverse seroconversion in allo-HSCT recipients with resolved HBV infection. A highly sensitive HBV-DNA assay (TaqMan-PCR) allowed early identification of the individual patients at risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; ACUTE VIRAL-HEPATITIS; REVERSE SEROCONVERSION; CHRONIC GVHD; LAMIVUDINE TREATMENT; ANTI-HBS; PATIENT; PREVALENCE; MANAGEMENT; RECOVERY; haematopoietic stem cell transplantation; hepatitis B virus; reactivation; reverse seroconversion |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jul 2021 09:07 |
| Last Modified: | 20 Jul 2021 09:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37662 |
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