Mueller, F. U. and Loser, K. and Kleideiter, U. and Neumann, J. and von Wallbrunn, C. and Dobner, T. and Scheld, H. H. and Bantel, H. and Engels, I. H. and Schulze-Osthoff, K. and Schmitz, W. (2004) Transcription factor AP-2 alpha triggers apoptosis in cardiac myocytes. CELL DEATH AND DIFFERENTIATION, 11 (5). pp. 485-493. ISSN 1350-9047
Full text not available from this repository. (Request a copy)Abstract
Idiopathic-dilated cardiomyopathy (IDC) is a common primary myocardial disease of unknown etiology associated with apoptosis, cardiac dilatation, progressive heart failure and increased mortality. An elevation of the transcription factor activator protein 2alpha (AP-2alpha) is involved in vertebrate embryonic development and oncogenesis. Here, we show that AP-2alpha protein is expressed in the human heart and increased in human failing myocardium with IDC. Adenovirus-mediated overexpression of human AP-2alpha triggered apoptosis and increased mRNA levels of Bcl-2 family members Bax and Bcl-x in rat cardiomyocytes. Immunohistological analysis of human myocardium revealed an increased percentage of AP-2alpha-positive nuclei in IDC and, interestingly, a colocalization of AP-2alpha-positive but not-negative cells with a caspase-cleaved fragment of poly(ADP-ribose) polymerase. We suggest AP-2alpha as a novel cardiac regulator implicated in the activation of apoptosis in IDC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONGESTIVE-HEART-FAILURE; FACTOR AP-2; DNA-BINDING; CARDIOMYOCYTE APOPTOSIS; SIGNAL-TRANSDUCTION; MAMMARY-CARCINOMA; RETINOIC ACID; PROTEIN; EXPRESSION; GENE; activator protein 2 alpha; apoptosis; human heart failure; transcription factor; rat cardiomyocytes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Jul 2021 09:10 |
| Last Modified: | 20 Jul 2021 09:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37664 |
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