Ullrich, Evelyn and Salzmann-Manrique, Emilia and Bakhtiar, Shahrzad and Bremm, Melanie and Gerstner, Stephanie and Herrmann, Eva and Bader, Peter and Hoffmann, Petra and Holler, Ernst and Edinger, Matthias and Wolff, Daniel (2016) Relation between Acute GVHD and NK Cell Subset Reconstitution Following Allogeneic Stem Cell Transplantation. FRONTIERS IN IMMUNOLOGY, 7: 595. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
One of the major challenges of allogeneic stem cell transplantation (allo-SCT) is to reduce the risk of graft-versus-host disease (GVHD) while boosting the graft-versus-leukemia (GVL) effect. The reconstitution of natural killer (NK) cells following allo-SCT is of notable interest due to their known capability to induce GVL without GVHD. Here, in this study, we investigate the association between the incidence and severity of acute graft-versus-host disease (aGVHD) and the early reconstitution of NK cell subsets following allo-SCT. We analyzed 342 samples from 107 patients using flow cytometry, with a focus on immature CD56(high) and mature cytotoxic CD56(dim) NK cells. Longitudinal analysis of immune reconstitution after allo-SCT showed that the incidence of aGVHD was associated with a delayed expansion of the entire NK cell population, in particular the CD56(high) subset. Notably, the disturbed reconstitution of the CD56(high) NK cells also correlated with the severity of aGVHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; NATURAL-KILLER-CELLS; BONE-MARROW; IMMUNE RECONSTITUTION; UNRELATED DONORS; COUNTS; BLOOD; NK cell; NK cell subset; GVHD; SCT; immune reconstitution |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Apr 2019 11:18 |
| Last Modified: | 11 Apr 2019 11:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3771 |
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