Fuchs-Koelwel, B. and Koelwel, C. and Goepferich, Achim and Gabler, B. and Wiegrebe, E. and Lohmann, C. P. (2004) Tolerance of a new calcium alginate depot for controlled medication of the eye. OPHTHALMOLOGE, 101 (5). pp. 496-499. ISSN 0941-293X, 1433-0423
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Purpose. For an effective pharmaceutical treatment it is necessary in some cases to maintain a constant drug level over a certain period. This cannot be achieved by conventional eye drop application. Therefore, a new insert basically consisting of alginates with a different hydroxyethylcellulose (HEC) content was developed. The aim of this study was to evaluate the tolerance of these inserts applied to the conjunctival cul de sac. Methods. 24 healthy volunteers received the insert containing different concentrations of hydroxyethylcellulose (0%, 5%, 30%) for 1 up to 5 days. The eyes have been examined several times (including visual acuity, ocular surface morphology, break-up-time, Schirmer-Tear-Test). Subjective parameters were pain sensations or daily life disturbance. Results. After an initial conjunctival hyperemia and a mild foreign body sensation, the insert was well tolerated. No variations concerning the tolerance between the different concentrations of hydroxyethylcellulose were observed. Conclusion. This study showed good tolerance of the new calcium-alginate-insert applied to the ocular surface for controlled drug release.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; insert; tolerance; drug release; controlled release; eye surface |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Zentren des Universitätsklinikums Regensburg > Apotheke des UKR Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jul 2021 05:49 |
| Last Modified: | 21 Jul 2021 05:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37714 |
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