Foryst-Ludwig, Anna and Neumann, Manfred and Schneider-Brachert, Wulf and Naumann, Michael (2004) Curcumin blocks NF-kappa B and the motogenic response in Helicobacter pylori-infected epithelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 316 (4). pp. 1065-1072. ISSN 0006-291X
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Infection of epithelial cells by the microbial pathogen Helicobacter pylori leads to activation of the transcription factor nuclear factor kappaB (NF-kappaB), the induction of pro-inflammatory cytokine/chernokine genes, and the motogenic response (cell scattering). Here we report that H. pylori-induced NF-kappaB activation and the subsequent release of interleukin 8 (IL-8) are inhibited by curcumin (diferuloylmethane), a yellow pigment in turmeric (Curcuma longa L.). Our results demonstrate that curcumin inhibits IkappaBalpha degradation, the activity of IkappaB kinases alpha and beta (IKKalpha and beta), and NF-kappaB DNA-binding. The mitogen-activated protein kinases (MAPK), extracellular signal-regulated kinases 1/2 (ERK1/2) and p38, which are also activated by H. pylori infection, were not inhibited by curcumin. Further, the H. pylori-induced motogenic response was blocked by curcumin. We conclude that curcumin, due to inhibition of NF-kappaB activation and cell scattering, should be considered as a potential therapeutic agent effective against pathogenic processes initiated by H. pylori infection. (C) 2004 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TERMINAL KINASE; CAGA PROTEIN; ACTIVATION; EXPRESSION; INHIBITION; INDUCTION; ADHESION; RECEPTOR; CANCER; TRANSACTIVATION; Helicobacter pylori; curcumin; NF-kappa B; I kappa B; I kappa B kinases; interleukin-8; mitogen-activated protein kinases; cell scattering |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jul 2021 08:35 |
| Last Modified: | 21 Jul 2021 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37742 |
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