Stroebel, Philipp and Bauer, Andrea and Puppe, Bernhard and Kraushaar, Til and Krein, Axel and Toyka, Klaus and Gold, Ralf and Semik, Michael and Kiefer, Reinhard and Nix, Wilfred and Schalke, Berthold and Mueller-Hermelink, Hans Konrad and Marx, Alexander (2004) Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: A retrospective analysis. JOURNAL OF CLINICAL ONCOLOGY, 22 (8). pp. 1501-1509. ISSN 0732-183X, 1527-7755
Full text not available from this repository. (Request a copy)Abstract
Purpose Thymic epithelial tumors (TET) are rare epithelial neoplasms of the thymus with considerable histologic heterogeneity. This retrospective study focused on the correlation of WHO-defined TET histotypes with survival and tumor recurrence in a large cohort of patients receiving different modes of treatment. Patients and Methods Two hundred twenty-eight patients were followed for up to 21 years (median, 60 months; range, 1 to 252 months) after primary surgery. Forty-two patients received adjuvant radiotherapy (mean dose, 53 Gy), and 33 patients recieved adjuvant chemotherapy. Results Seventy-six (88%) of 86 patients with WHO type A, AB, and 131 thymomas were treated by surgery alone, with three tumor relapses after 3 to 10 years (median, 3.4 years). Twelve of 67 patients with WHO type B2 and B3 thymomas in Masaoka stages I and II were treated by adjuvant radiotherapy without evidence of tumor recurrence after 1 to 12 years (median, 4 years). Among 75 patients with 32 and B3 thymomas with incomplete resection or a tumor stage III or higher, the recurrence rate was 34% (n = 23) after 0.5 to 17 years (median, 5 years) in patients receiving adjuvant radiochemotherapy, compared to 78% (seven of nine patients) in patients without adjuvant radiochemotherapy. Incomplete tumor resection was associated with a high recurrence rate (65%) and a poor prognosis (P < .01). Conclusion The long-term outcome of TET patients is related to tumor stage, WHO histotype, completeness of surgical removal, and type of treatment. Prospective trials are warranted to formally address the efficacy of adjuvant therapy in the treatment of localized and advanced malignant TETs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HISTOLOGIC CLASSIFICATION; EPITHELIAL TUMORS; MULTIMODALITY TREATMENT; ADJUVANT RADIATION; PROGNOSTIC-FACTORS; II THYMOMA; CYCLOPHOSPHAMIDE; THERAPY; CISPLATIN; NEOPLASMS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jul 2021 08:57 |
| Last Modified: | 21 Jul 2021 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37748 |
Actions (login required)
 |
View Item |
