Hartmann, Pia and Herholz, K. and Salzberger, B. and Petereit, H. F. (2004) Unusual and severe symptomatic impairment of neutrophil function after one cycle of temozolomide in patients with malignant glioma. ANNALS OF HEMATOLOGY, 83 (4). pp. 212-217. ISSN 0939-5555, 1432-0584
Full text not available from this repository. (Request a copy)Abstract
Temozolomide, a recently approved cytotoxic agent for the treatment of malignant glioma, has shown promising results in the treatment studies published so far. However, cytopenia and related infectious complications have been reported in 2-8% of cases. Here we present three treatment-naive patients with malignant glioma experiencing cytopenia and/or infectious complications after the first cycle of temozolomide. Neutrophils obtained from each patient up to 6 weeks after the end of the temozolomide application showed normal phagocytic capacity but decreased oxygen radical production and thus impairment of microcidal activity. Our data suggest that a prolonged impairment of the immunological defense may occur in temozolomide-treated patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; PHASE-II TRIAL; QUALITY-OF-LIFE; G-CSF; GLIOBLASTOMA-MULTIFORME; INTERFERON-GAMMA; IN-VITRO; GM-CSF; ANAPLASTIC ASTROCYTOMA; ASPERGILLUS-FUMIGATUS; neutrophils; temozolomide; malignant glioma; drug effects; immunology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jul 2021 12:18 |
| Last Modified: | 21 Jul 2021 12:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37760 |
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