Dahlke, Marc H. and Popp, Felix C. and Larsen, Stephen and Schlitt, Hans J. and Rasko, John E.J. (2004) Stem cell therapy of the liver - Fusion or fiction? LIVER TRANSPLANTATION, 10 (4). pp. 471-479. ISSN 1527-6465, 1527-6473
Full text not available from this repository. (Request a copy)Abstract
Various stem cell populations have been described in distinct models of liver regeneration. This review provides an overview of these different stem cell populations aimed at unifying diverse views of liver stem cell biology. Embryonic stem cells, hemopoietic stem cells, mesenchymal stem cells, liver-derived hepatic stem cells, bone marrow-derived hepatic stem cells, and mature hepatocytes (as cells with stemlike properties) are considered separately. In so doing, we seek to clarify the nomenclature of putative liver stem cell types. Experiments that address the question of cellular fusion versus transdifferentiation as explanations for observed liver regeneration are highlighted. This review concludes with a series of open questions that should be addressed in the context of clinical liver disease before attempts at human therapeutic interventions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | XENOGENEIC HEPATOCYTE TRANSPLANTATION; RETRORSINE-EXPOSED RATS; MARROW-DERIVED CELLS; UMBILICAL-CORD BLOOD; HEPATIC OVAL CELLS; BONE-MARROW; PROGENITOR CELLS; IN-VIVO; PERIPHERAL-BLOOD; MOUSE-LIVER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Aug 2021 13:29 |
| Last Modified: | 03 Aug 2021 13:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37823 |
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