Eichhammer, Peter and Wiegand, Rainer and Kharraz, Alexander and Langguth, Berthold and Binder, Harald and Hajak, Goeran (2004) Cortical excitability in neuroleptic-naive first-episode schizophrenic patients. SCHIZOPHRENIA RESEARCH, 67 (2-3). pp. 253-259. ISSN 0920-9964, 1573-2509
Full text not available from this repository. (Request a copy)Abstract
Transcranial magnetic stimulation (TMS) provides an intriguing in vivo method to investigate motor cortex excitability in men. This offers new insights into the neurophysiological basis of neuropsychiatric diseases. Earlier TMS studies in patients with schizophrenia revealed inconsistent results, probably due to major confounding variables like state of medication and stage of illness. To control for these effects, we studied two TMS paradigms in 21 drug-naive first-episode schizophrenic patients and 21 age- and sex-matched healthy controls. The patient group demonstrated a significant lower resting motor threshold as compared with healthy controls, whereas TMS paradigms of intracortical inhibition and intracortical facilitation failed to show significant differences between patients and controls. This pattern of TMS parameters is similar to that obtained in healthy volunteers investigated under increasing doses of ketamine, a central acting drug known to produce psychosis-like effects. In agreement with recent results of functional imaging, our neurophysiological findings suggest that drug-induced and naturally occurring psychosis may share a common pathway, which may base on dysfunctional glutamatergic mechanisms. (C) 2003 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; TRANSCALLOSAL INHIBITION; PREFRONTAL CORTEX; MESSENGER-RNAS; GLUTAMATE; RESPONSES; KETAMINE; BRAIN; MODEL; transcranial magnetic stimulation; cortical excitability; schizophrenia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jul 2021 07:14 |
| Last Modified: | 26 Jul 2021 07:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37849 |
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