Dahlke, Marc H. and Aselmann, Heiko and Ceylan, Dilek and Bellin, Tobias and Flemming, Peer and Meier, Peter N and Oldhafer, Karl and Klempnauer, Juergen and Schlitt, Hans J. and Piso, Pompiliu (2004) Effectiveness of peripheral hepatogastrostomy versus hepatojejunostomy in the treatment of obstructive cholestasis: Results of an experimental model. SURGERY TODAY, 34 (4). pp. 349-353. ISSN 0941-1291
Full text not available from this repository.Abstract
Purpose. Tumors of the liver hilum frequently cause obstructive cholestasis. When a curative resection of the tumor is impossible, palliative bile drainage is indicated. A hepatojejunostomy is performed if conservative treatment fails or if irresectability is proven during an initial laparotomy. In patients with peritoneal carcinosis and mesentery retraction, a hepatogastrostomy may represent a helpful alternative. An experimental study was designed to compare the bile drainage effectiveness of a hepatogastrostomy versus a hepatojejunostomy. Methods. Two-month-old outbred piglets were used in all experiments. The animals were randomized into three groups (hepatojejunostomy, hepatogastrostomy alone, hepatogastrostomy and proton pump inhibitors). Obstructive cholestasis was induced by common bile duct ligation; hepatojejunostomy and hepatogastrostomy were performed 2 weeks later. The serum bilirubin levels were monitored weekly. All animals were killed 4 weeks after the drainage operation. Results. Following a hepatojejunostomy (n = 5) all animals showed decreasing cholestasis parameters. All animals (n = 3) died within 3-5 days after a hepatogastrostomy due to gastrointestinal bleeding caused by gastric ulcers and ulcers of the liver surface. The administration of pantoprazole prevented these bleeding complications. In animals treated by hepatogastrostomy and proton pump inhibitors (n = 5), bile drainage effectiveness was similar to that following hepatojejunostomy. Conclusion. A hepatogastrostomy represents an alternative treatment option for surgical bile drainage with a similar effectiveness to that of a hepatojejunostomy. To prevent postoperative gastrointestinal bleeding, proton pump inhibitors should be used.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BILE-DUCT; LIVER-TRANSPLANTATION; PALLIATIVE TREATMENT; STRICTURES; HEPATICOJEJUNOSTOMY; GALLBLADDER; SURGERY; BENIGN; CANCER; cholestasis; hepatojejunostomy; hepatogastrostomy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jul 2021 07:17 |
| Last Modified: | 26 Jul 2021 07:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37851 |
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