Haenssle, Holger A. and Krause, Stefan W. and Emmert, Steffen and Zutt, Markus and Kretschmer, Lutz and Schmidberger, Heinz and Andreesen, Reinhard and Soruri, Afsaneh (2004) Hybrid cell vaccination in metastatic melanoma - Clinical and immunologic results of a phase I/II study. JOURNAL OF IMMUNOTHERAPY, 27 (2). pp. 147-155. ISSN 1053-8550
Full text not available from this repository. (Request a copy)Abstract
Hybrid cell vaccination with cell fusion products (CFPs) of autologous turner cells and mature allogenic MHC 11 hearing dendritic cells has been described to induce cytotoxic T lymphocyte (CTL)-mediated immune responses. The aim of this Study was to assess safety, antitumor activity, and immune responses of a CFP-vaccine in patients with disseminated malignant melanoma. In a phase I/II study, we treated I I patients by monthly intracutaneous or subcutaneous application of a CFP vaccine generated by electrofusion of autologous melanoma cells with mature allogenic dendritic cells. In addition, patients received subcutaneous low-dose interleukin-2 injections for 6 days after each vaccination. No serious adverse effects were observed. Ten patients showed progressive disease and or e patient had a short-lasting stable disease. None of the patients developed a positive delayed-type hypersensitivity reaction against irradiated autologous melanoma cells. In 2 patients, who were monitored in more detail, we found no evidence of induction of a specific antimelanoma T-cell response by analyzing the proliferation, cytokine secretion, and cytotoxicity of their T cells toward autologous melanoma cells. No unequivocal beneficial effects of the used CFP vaccine Could be demonstrated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PULSED DENDRITIC CELLS; HUMAN TUMOR-ANTIGENS; T-CELLS; INTERLEUKIN-10 PRODUCTION; THERAPEUTIC-EFFICACY; MALIGNANT-MELANOMA; IN-VITRO; CANCER; INDUCTION; LYMPHOCYTES; melanoma; vaccination; cell fusion; hybrid cells; dendritic cells; therapy; clinical trial |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Jul 2021 11:07 |
| Last Modified: | 28 Jul 2021 11:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37935 |
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