Licht, Anna-K. and Schulmeyer, Frank and Allert, Max and Held, Paul and Woenckhaus, Matthias and Strutz, Juergen (2004) Vertigo and hearing disturbance as the first sign of a glioblastoma (World Health Organization Grade IV). OTOLOGY & NEUROTOLOGY, 25 (2). pp. 174-177. ISSN 1531-7129
Full text not available from this repository. (Request a copy)Abstract
Objective: To describe vertigo and hearing disturbance as a first sign of glioblastoma. Study Design: Case report. Setting: Ear, Nose, and Throat Department of the University of Regensberg, Germany. Primary Care Center. Patients: A patient with a left temporal glioblastoma. Results: A 67-year-old man presented with a 2-month history of vertigo and hearing disturbance. Radiological imaging revealed a left temporal tumor with dural inflation and erosion of the petrous bone and superior semicircular duct. The surgery involved total resection of the tumor and resurfacing of the gap in the superior canal. The histopathological examination revealed World Health Trade Organization IV glioblastoma. Postoperatively, the debilitating symptoms were relieved and the patient received radiation therapy. Tumor progression indicated a recraniotomy and a mastoidectomy. The tumor was only partially resected, and required chemotherapy. It subsequently developed otoliquorrhea and required a remastoidectomy. Histopathology of a pathological fracture of the X thoracic vertebra revealed a metastasis of the known glioblastoma. The patient died from respiratory distress syndrome. Conclusion: To the best of our knowledge, we are presenting the first case with transdural infiltration of bony structures by a glioblastoma at the moment of diagnosis. The transdural spread could be via the sinus petrosus and along the nervous petrosus major in the petrosal bone. Superior canal dehiscence syndrome should be considered in the differential diagnosis of vertigo and hearing disturbance. Two different processes for the etiology of the superior canal dehiscence syndrome are discussed previously in the literature; however, we present a new entity with a tumor-cause dehiscence of the bone overlying the superior canal.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; EXTRANEURAL METASTASES; PREVIOUS CRANIOTOMY; EXTRACRANIAL METASTASES; MALIGNANT ASTROCYTOMA; ABSENCE; MULTIFORME; GLIOMAS; TUMORS; DEHISCENCE; glioblastoma; hearing disturbance; surgery; vertigo; superior canal dehiscence syndrome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2021 09:22 |
| Last Modified: | 27 Jul 2021 09:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37964 |
Actions (login required)
 |
View Item |
