Sell, Stefan and Phillips, Oliver and Handel, Martin (2004) No difference between two doses of diclofenac in prophylaxis of heterotopic ossifications after total hip arthroplasty. ACTA ORTHOPAEDICA SCANDINAVICA, 75 (1). pp. 45-49. ISSN 0001-6470
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Background In a monocentric, randomized, placebo-controlled double-blind study, we investigated the efficacy of two doses of diclofenac-cholestyramine for the prevention of heterotopic ossification (110). Patients The study comprised 245 patients undergoing total hip arthroplasty (THA). Results With 150 mg cholestyramine-bound diclofenac (2 x I capsule Voltaren(R) resinate) daily during a postoperative period of 14 days, 19% of patients showed slight HO (Brooker grade 1), and no patient had more severe ossifications (grades 2-4). In the group receiving 75 mg daily (1 x 1 capsule), 17% of patients showed grade I HO and 4% grade 2 HO. No patient had grades 3-4 HO. No differences in clinical results were seen between the two groups 6 months after THA. Interpretation Since the rate of adverse gastrointestinal events was lower (23% versus 38 %, p = 0.02) in the group receiving the lower dose, we recommend it.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ECTOPIC OSSIFICATION; REPLACEMENT; PREVENTION; SODIUM; JOINT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2021 14:27 |
| Last Modified: | 27 Jul 2021 14:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38006 |
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