Diep, Q. N. and Benkirane, K. and Amiri, F. and Cohn, J. S. and Endemann, Dierk and Schiffrin, E. L. (2004) PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 36 (2). pp. 295-304. ISSN 0022-2828, 1095-8584
Full text not available from this repository. (Request a copy)Abstract
Background. Peroxisome proliferator-activated receptor (PPAR)a is highly expressed in the heart. PPARalpha may play a role in cardiac hypertrophy, but effects on cardiac function, inflammation, and fibrosis are unknown. We tested the hypothesis that the PPARalpha activator fenofibrate prevents myocardial inflammation and fibrosis in angiotensin (Ang) II-infused rats. Methods and results. Sprague Dawley rats received Ang II (120 ng/kg/min subcutaneously), fenofibrate (100 mg/kg/d p.o.), or Ang II + fenotibrate. After 7 d, systolic blood pressure (mmHg) was elevated (P < 0.01) in Ang II-infused rats (173 +/- 4) vs. controls (115 +/- 2) and reduced by fenofibrate (137 +/- 5). Electrophoretic mobility shift assay demonstrated that Ang II upregulated cardiac nuclear factor kappa B activity by 50%. Ang II significantly increased cardiac expression of vascular-cell adhesion molecule-1, platelet endothelial cell adhesion molecule, and intercellular adhesion molecule-1. Increases in expression of these inflammatory mediators were normalized by fenofibrate. Ang II-induced expression of transforming growth factor-beta1, collagen deposition, and macrophage infiltration were partially prevented by fenofibrate. Conclusions. The PPARalpha activator fenofibrate prevented development of hypertension, and improved myocardial inflammation and collagen deposition in Ang II-infused rats. The hypolipidemic drug fenofibrate may be useful in prevention and treatment of myocardial disease associated with hypertension and hyperlipidemia. (C) 2003 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-KAPPA-B; RECEPTOR-ALPHA; INDUCED HYPERTENSION; HYPERTROPHIC GROWTH; ADHESION MOLECULE-1; ENDOTHELIAL-CELLS; CARDIAC FIBROSIS; AT(2) RECEPTORS; FATTY-ACIDS; EXPRESSION; peroxisome proliferator activated receptor; hypertension; cardiac remodeling; inflammation; angiotensin II |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2021 08:42 |
| Last Modified: | 02 Aug 2021 08:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38040 |
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