Dahlke, Marc H. and Larsen, S. R. and Rasko, J. E J and Schlitt, Hans Juergen (2004) The biology of CD45 and its use as a therapeutic target. LEUKEMIA & LYMPHOMA, 45 (2). pp. 229-236. ISSN 1042-8194
Full text not available from this repository.Abstract
All mature hemopoietic lineage cells, with exclusion of platelets and mature erythrocytes, share the surface expression of a transmembrane phosphatase, the CD45 molecule. It is also present on hemopoietic stem cells and most leukemic clones and therefore presents as an appropriate target for immunotherapy with anti-CD45 antibodies. This short review details the biology of CD45 and its recent targeting for both treatment of malignant disorders and tolerance induction. In particular, the question of potential stem cell depletion for induction of central tolerance or depletion of malignant hemopoietic cells is addressed. Mechanisms underlying the effects downstream of CD45 binding to the cell surface are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-TYROSINE-PHOSPHATASE; ANTI-CD45 MONOCLONAL-ANTIBODY; COMMON ANTIGEN CD45; SEVERE COMBINED IMMUNODEFICIENCY; SYSTEMIC LUPUS-ERYTHEMATOSUS; STEM-CELL TRANSPLANTATION; JANUS KINASE PHOSPHATASE; HUMAN B-CELLS; POINT MUTATION; LYMPHOCYTE-ACTIVATION; CD45; tolerance; antibody mediated therapy; hemopoiesis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2021 08:58 |
| Last Modified: | 02 Aug 2021 08:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38045 |
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