Lottner, Christian and Knuechel, Ruth and Bernhardt, Guenther and Brunner, Henri (2004) Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin-platinum(II) conjugates. CANCER LETTERS, 203 (2). pp. 171-180. ISSN 0304-3835
Full text not available from this repository. (Request a copy)Abstract
Four porphyrin-platinum complexes, conceived a, a new approach in cancer therapy by combining the cytostatic activity of cisplatin or oxaliplatin and the photodynamic effect of hematoporphyrin in the same molecule, were studied in detail with respect to solubility and stability in cell culture medium as well as in terms of cytotoxicity and phototoxicity against J82 bladder cancer cells and UROtsa, normal urothelial cells. Thin study demonstrated that the most active and promising compound among the porphyrin-platinum conjugates investigated was the water-soluble porphyrin-platinum complex 4 (diammine{7,12-bis[1-(polyethyleneglycol-750-monomethylether-1-yl)ethyl]-3,8,13,17-tetramethylporphyrin-2,18-dipropionato}platinum(II)) which exhibited a synergistic antiproliferative effect compared to cisplatin and hematoporphyrin alone or a combination of the drugs. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OXALIPLATIN; PLATINUM; CANCER; porphyrin-platinum conjugates; bladder cancer; photodynamic therapy; chemotherapy; synergistic effect |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Pathologie Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institut für Anorganische Chemie > Alumni or Retired Professors > Prof. Dr. Henri Brunner |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2021 11:13 |
| Last Modified: | 02 Aug 2021 11:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38073 |
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