Chen, Danqing and Hackl, Wolfgang and Ortmann, Olaf and Treeck, Oliver (2004) Effects of a combination of exemestane and paclitaxel on human tumor cells in vitro. ANTI-CANCER DRUGS, 15 (1). pp. 55-61. ISSN 0959-4973, 1473-5741
Full text not available from this repository. (Request a copy)Abstract
Exemestane, a non-steroidal aromatase inhibitor that shuts down estrogen synthesis, and paclitaxel, an antineoplastic drug, inhibiting microtubule formation and interfering with the cells potential to proliferate, are well established treatments for metastatic breast cancer. Given that exemestane is a treatment for hormone-sensitive tumors in postmenopausal women with more favorable prognosis, while paclitaxel is normally used for women suffering from hormone-insensitive breast cancers with less favorable prognoses, there is currently no experience with the combination of the two drugs. In order to find out to what extent exemestane and paclitaxel add to each other's effects when given concomitantly, the effect of the two drugs alone and in combination on the growth of various gynecological tumor cell lines was assessed. Tumor cell growth was measured according to the cell titer cell proliferation technique, also referred to as the MTS assay, by measurement of relative cell numbers. In gynecological cancer cells expressing aromatase, the effect of a treatment with paclitaxel (10 nM) on cell growth was enhanced by co-treatment with exemestane. This additive effect was independent of ERalpha expression, but dependent on the presence of androstenedione. It was observed in HEC-1A and Ishikawa endometrial adenocarcinoma cells as well as in SK-OV-3 ovarian cancer and in MDA-MB-231 breast cancer cells. Our findings suggest that a combination of paclitaxel with exemestane might be beneficial for the treatment of aromatase-positive gynecological cancer, because it may allow us to reduce the paclitaxel dosage and therefore the toxicity of the treatment. (C) 2004 Lippincott Williams Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADVANCED BREAST-CANCER; NONSTEROIDAL AROMATASE INHIBITORS; PHASE-II TRIAL; POSTMENOPAUSAL WOMEN; ESTROGEN-RECEPTOR; ACTIVATION; EXPRESSION; FAILURE; aromatase; cell growth; exemestane; paclitaxel; tumor cell line |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Aug 2021 11:02 |
| Last Modified: | 03 Aug 2021 11:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38114 |
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