Veleri, Shobi and Wuelbeck, Corinna (2004) Unique self-sustaining circadian oscillators within the brain of Drosophila melanogaster. CHRONOBIOLOGY INTERNATIONAL, 21 (3). pp. 329-342. ISSN 0742-0528, 1525-6073
Full text not available from this repository. (Request a copy)Abstract
In Drosophila circadian rhythms persist in constant darkness (DD). The small ventral Lateral Neurons (s-LNv) mainly control the behavioral circadian rhythm in consortium with the large ventral Lateral Neurons (l-LNv) and dorsal Lateral Neurons (LNd). It is believed that the molecular oscillations of clock genes are the source of this persistent behavior. Indeed the s-LNv, LNd, Dorsal Neurons (DN)-DN2 and DN3 displayed self-sustained molecular oscillations in DD both at RNA and protein levels, except the DN2 oscillates in anti-phase. In contrast, the l-LNv and DN1 displayed self-sustained oscillations at the RNA level, but protein oscillations quickly dampened. Having self-sustained and dampened molecular oscillators together in the DN groups suggested that they play different roles. However, all DN groups seemed to contribute together to the light-dark (LD) behavioral rhythm. The LD entrainment of LN oscillators is achieved through Rhodopsin (RH) and Cryptochrome (CRY). CRY's expression in all DN groups implicates also its role in LD entrainment of DN, like in DN1. However, mutations in cry and glass that did not inflict LD synchronization of the DN2, DN3 oscillator implicate the existence of a novel photoreceptor at least in DN3.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIOD CLOCK GENE; BEHAVIORAL RHYTHMS; NERVOUS-SYSTEM; DISCONNECTED MUTANTS; EXPRESSION PATTERNS; TEMPORAL EXPRESSION; PACEMAKER NEURONS; LATERAL NEURONS; MOSAIC ANALYSIS; TIMELESS GENES; circadian oscillator; self-sustained; dorsal neurons; promoterless period; luciferase reporter; cryptochrome |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Jul 2021 09:49 |
| Last Modified: | 20 Jul 2021 09:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38133 |
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