Meurer, M. and Fartasch, M. and Albrecht, G. and Vogt, Thomas and Worm, M. and Ruzicka, T. and Altmeyer, P. J. and Schneider, D. and Weidinger, G. and Braeutigam, M. (2004) Long-term efficacy and safety of pimecrolimus cream 1% in adults with moderate atopic dermatitis. DERMATOLOGY, 208 (4). pp. 365-372. ISSN 1018-8665
Full text not available from this repository. (Request a copy)Abstract
Background: Pimecrolimus cream 1% is a non-steroid, selective inflammatory cytokine inhibitor indicated for atopic dermatitis (AD). Objective: To compare the safety and efficacy of pimecrolimus cream 1%-based treatment versus conventional therapy in adults with moderate AD. Methods: Patients were randomized to receive pimecrolimus cream 1% (n = 62) or vehicle (n = 68) at the first signs/symptoms of AD, for 24 weeks as required. A moderately potent topical corticosteroid (prednicarbate 0.25% cream) was allowed in both groups to treat flares. Results: Corticosteroids were required on fewer days in the pimecrolimus group, compared with the vehicle group (9.7 vs. 37.8%, p < 0.001). Furthermore, 59.7% of pimecrolimus-treated patients experienced no flares during the study period, compared with 22.1% of vehicle-treated patients (p < 0.001). Pimecrolimus cream 1% was well tolerated throughout the study. Conclusion: For adults with moderate AD, pimecrolimus cream 1% is well tolerated, reduces the incidence of flares, reduces/eliminates corticosteroid use, improves long-term disease control and enhances the patients' quality of life. Copyright (C) 2004 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SDZ ASM 981; ANTIINFLAMMATORY DRUG; SKIN DISEASES; MAST-CELLS; MANAGEMENT; ECZEMA; PHARMACOLOGY; CHILDREN; INFANTS; RELEASE; pimecrolimus cream 1%; Elidel (R); atopic dermatitis; moderate disease; eczema; long term management; topical corticosteroids |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2021 11:26 |
| Last Modified: | 02 Aug 2021 11:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38148 |
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