Zietz, Bettina and Buechler, Christa and Drobnik, Wolfgang and Herfarth, Hans and Schoelmerich, Juergen and Schaeffler, Andreas (2004) Allelic frequency of the PAI-1 4G/5G promoter polymorphism in patients with type 2 diabetes mellitus and lack of association with PAI-1 plasma levels. ENDOCRINE RESEARCH, 30 (3). pp. 443-453. ISSN 0743-5800, 1532-4206
Full text not available from this repository. (Request a copy)Abstract
Plasminogen activator inhibitor-1 (PAI-1) levels were found to be associated with obesity, indicating that adipocytes might influence PAI-1 plasma levels. In addition, the 4G/5G promoter polymorphism of the PAI-1 gene possibly modulates PAI-1 gene transcription and, as a consequence, PAI-1 plasma levels. Metabolic parameters, diabetes complications, PAI-1 plasma levels, and PAI-1 promoter genotypes were determined and were tested for correlation in 547 Caucasian patients with type 2 diabetes. Genotyping was performed by using allele-specific PCR, and PAI-1 plasma levels were measured in 547 well-characterized subjects with type 2 diabetes. The allelic frequencies of the polymorphism (0.56 for the 4G-genotype, 0.44 for the 5G-genotype) were not different from those observed in nondiabetic controls. The PAT-I concentration was positively associated with MI, but not with the 4G/5G polymorphism. Statistical analysis of metabolic parameters, diabetic complications, and the 4G/5G polymorphism revealed that serum fibrinogen levels were significantly higher in the 4G/4G subgroup compared with the 4G/5G and 5G/5G subgroups. The correlation between serum fibrinogen and 4G allele remained significant, even when additional variables, such as gender, age, BMI, duration of diabetes, and HbA(1c), were controlled. In patients with type 2 diabetes mellitus, the PAI-1 4G/5G promoter polymorphism does not predict PAI-1 plasma levels and is not associated with common metabolic parameters besides fibrinogen levels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLASMINOGEN-ACTIVATOR INHIBITOR-1; CORONARY-ARTERY-DISEASE; HUMAN ADIPOSE-TISSUE; MYOCARDIAL-INFARCTION; GENE-EXPRESSION; INSULIN-RESISTANCE; VASCULAR-DISEASE; VISCERAL FAT; RISK-FACTOR; FACTOR-VII; PAI-1; promoter; polymorphism; fibrinogen; diabetes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2021 11:39 |
| Last Modified: | 02 Aug 2021 11:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38152 |
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