Spicuzza, Lucia and Casiraghi, N. and Gamboa, A. and Keyl, C. and Schneider, A. and Mori, A. and Leon-Velarde, F. and Di Maria, G. U. and Bernardi, L. (2004) Sleep-related hypoxaemia and excessive erythrocytosis in Andean high-altitude natives. EUROPEAN RESPIRATORY JOURNAL, 23 (1). pp. 41-46. ISSN 0903-1936, 1399-3003
Full text not available from this repository. (Request a copy)Abstract
To determine whether nocturnal hypoxaemia contributes to the excessive erythrocytosis (EE) in Andean natives, standard polysomnographies were performed in 10 patients with EE and in 10 controls (mean haematocrit 76.6 +/- 1.3% and 54.4 +/- 0.8%, respectively) living at an altitude of 4,380 m. In addition, the effect of O-2 administration for 1 h prior to sleep, and the relationship between the hypoxic/ hypercapnic ventilatory response and the apnoea/hypopnoea index (AHI) during sleep were studied. Awake arterial oxygen saturation (Sa,O-2) was significantly lower in patients with EE than in controls (83.7 +/- 0.3% versus 85.6 +/- 0.4%). In both groups, the mean Sa,O-2 significantly decreased during sleep (to 80.0 +/- 0.80% in EE and to 82.8 +/- 0.5% in controls). The mean Sa,O-2 values remained significantly lower in patients with EE than in controls at all times of the night, and patients with EE spent significantly more time than the controls with an Sa,O-2 of <80%. There were no differences between the two groups in the number and duration of the apnoeas/hypopnoeas. None of these variables were affected by O-2 administration. In both groups the AHI positively correlated with the hypercapnic ventilatory response. Andean natives undergo minor respiratory disorders during sleep. The reduction in oxygen saturation found in subjects with excessive erythrocytosis was small, yet consistent and potentially important, as it remained below the threshold known for the increase in erythropoietin stimulation. This may be an important factor promoting erythropoiesis, but its relevance needs to be further explored.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC MOUNTAIN-SICKNESS; RESPIRATORY MOTOR CONTROL; CHEMOREFLEX RESPONSE; HYPOXIA; ACCLIMATIZATION; HYPERCAPNIA; SATURATION; PLASTICITY; APNEA; RISK; autonomic nervous system; chronic mountain sickness; erythropoietin high altitude; polycythaemia sleep disturbances |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 08:12 |
| Last Modified: | 04 Aug 2021 08:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38156 |
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