Poser, I. and Bosserhoff, Anja K. (2004) Transcription factors involved in development and progression of malignant melanoma. HISTOLOGY AND HISTOPATHOLOGY, 19 (1). pp. 173-188. ISSN 0213-3911, 1699-5848
Full text not available from this repository. (Request a copy)Abstract
Up to date many genes are known to be deregulated in tumor development and progression. Genes important in tumorigenesis belong to families such as proteases, kinases and receptors. However, an important family of proteins is rarely discussed: the mediators of transcriptional control, the transcription factors. Usually, changes in transcription factor expression or activity can lead to more than just one downstream modification, as transcription factors are higher, thinking in a hierarchical way of expression control. In this review we summarize the role of the transcription factors AP-1, AP-2alpha, CREB, CtBP, ETS-1, HMGB1, LEF/TCF/beta-catenin, MITF, NFkappaB, PAX3, SKI, Snail and STAT in carcinogenesis focusing on melanoma development and progression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; TRANSFORMING-GROWTH-FACTOR; E-CADHERIN EXPRESSION; TCR-ALPHA ENHANCER; BETA-CATENIN; DNA-BINDING; SIGNAL-TRANSDUCTION; CELL-LINES; TGF-BETA; COLORECTAL-CANCER; malignant melanoma; tumor development; transcription factor; metastasis; transcriptional regulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Jul 2021 09:33 |
| Last Modified: | 20 Jul 2021 09:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38164 |
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