Fischer, Veronika and Touraud, Didier and Kunz, Werner (2016) Eco-friendly one pot synthesis of caffeic acid phenethyl ester (CAPE) via an in-situ formed deep eutectic solvent. SUSTAINABLE CHEMISTRY AND PHARMACY, 4. pp. 40-45. ISSN 2352-5541,
Full text not available from this repository. (Request a copy)Abstract
In this paper, a new strategy towards the synthesis of caffeic acid phenethyl ester (CAPE) is introduced. The reaction is carried out in a deep eutectic solvent made of caffeic acid and choline chloride. Caffeic acid is used as part of the solvent and as reactant. Phenethyl alcohol is soluble in this mixture in every molar ratio, and as a consequence no additional solvent is necessary. Reaction conditions were optimised with respect to the molar ratio of phenethyl alcohol and caffeic acid, and by varying the amount and nature of the acid catalyst as well as the reaction time. The obtained CAPE ester could easily be separated from the reaction mixture by simply adding water to destroy the deep eutectic by solubilisation of choline chloride in the aqueous phase. (C) 2016 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-MELTING MIXTURES; IONIC LIQUIDS; CHOLINE-CHLORIDE; GREEN EXTRACTION; CARBOXYLIC-ACIDS; NATURAL-PRODUCTS; TUMOR PROMOTION; MOUSE SKIN; KAPPA-B; PROPOLIS; Caffeic acid phenethyl ester; Deep eutectic solvent; Green synthesis; Green solvent; Miscibility; One pot synthesis |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Apr 2019 05:50 |
| Last Modified: | 12 Apr 2019 05:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3817 |
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