Richter, Claus-M. and Godes, Michael and Wagner, Charlotte and Maser-Gluth, Christiane and Herzfeld, Sophia and Dorn, Maren and Priem, Friedrich and Slowinski, Torsten and Bauer, Christian and Schneider, Wolfgang and Neumayer, Hans-H. and Kurtz, Armin and Hocher, Berthold (2004) Chronic cyclooxygenase-2 in pressure and kidney function inhibition does not alter blood in renovascular hypertensive rats. JOURNAL OF HYPERTENSION, 22 (1). pp. 191-198. ISSN 0263-6352, 1473-5598
Full text not available from this repository. (Request a copy)Abstract
Background It has been shown that the macula densa participates in the regulation of increased renin expression in two-kidney one-clip (2K1C) renovascular hypertension. Prostaglandins might be one of the mediators of macula densa function, because the cyclooxygenase-2 (COX-2), one of the rate-limiting enzymes of the prostaglandin pathway, is upregulated in 2k1C renovascular hypertensive rats. We tested the effect of chronic COX-2 inhibition on blood pressure, urinary aldosterone excretion and kidney morphology, as well as kidney function. Methods Four groups were established: two groups of 2K1C renovascular hypertensive rats treated with the specific COX-2 inhibitor Celecoxib (cele) (15 mg/kg per day) or placebo immediately after operation, and two sham-operated control groups fed with Celecoxib or placebo. Results Long-term COX-2 inhibition in 2K1 C renovascular hypertensive rats did not alter blood pressure at any point of time. Urinary aldosterone excretion was elevated by clipping the renal artery (2K1C, 8.1 +/- 1.9, versus controls, 3.6 +/- 0.5 ng/24 h; P = 0.05) but was not influenced by treatment with Celecoxib. Also, Celecoxib treatment did not alter glomerular filtration rate (GFR), serum sodium, serum creatinine, serum urea or proteinuria in 2K1C renovascular hypertensive rats. Interstitial fibrosis of the left clipped kidney was markedly reduced (2K1C, 6.19 +/- 0.83% versus 2K1C + cele 3.00 +/- 0.68% of total area; P = 0.012), whereas the interstitial fibrosis of the nonclipped kidney or the glomerulosclerosis of both kidneys were not affected by Celecoxib treatment. Conclusions Celecoxib reduces the interstitial fibrosis of the clipped kidney. Blood pressure, urinary aldosterone excretion or whole kidney function were not affected in renal hypertensive rats. (C) 2004 Lippincott Williams Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MURINE LUPUS NEPHRITIS; RENAL-FUNCTION; RECEPTOR BLOCKADE; RENIN; EXPRESSION; FIBROSIS; SYSTEM; CELLS; cyclooxygenase-2; COX-2; inhibition; two-kidney one-clip; Celecoxib; 2K1C; renovascular hypertension; rat; therapy; aldosterone |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 09:44 |
| Last Modified: | 04 Aug 2021 09:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38187 |
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