Schoenherr, Elke and Sunderkoetter, Cord and Schaefer, Liliana and Thanos, Solon and Graessel, Susanne and Oldberg, Ake and Iozzo, Renato V. and Young, Marian F. and Kresse, Hans (2004) Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. JOURNAL OF VASCULAR RESEARCH, 41 (6). pp. 499-508. ISSN 1018-1172, 1423-0135
Full text not available from this repository. (Request a copy)Abstract
Small leucine-rich proteoglycans play important roles in the organization of the extracellular matrix as well as for the regulation of cell behavior; two biological processes that are essential for angiogenesis. We investigated consequences of the targeted ablation of decorin (DCN), biglycan (BGN) and fibromodulin (FMOD) genes on inflammation-induced angiogenesis in the cornea. In wildtype mice, DCN was localized exclusively to the corneal stroma, while FMOD and BGN were more prominently expressed in epithelial cells. Endothelial cells from limbus blood vessels expressed BGN and FMOD, but no DCN. However, after induction of angiogenesis by chemical cauterization, DCN was expressed in the newly formed capillaries, together with BGN and FMOD. Notably, in DCN-deficient mice, the growth of vessels was significantly diminished, whereas it did not significantly change in FMOD- or BGN-deficient animals. Moreover, blood vessels of DCN-deficient mice exhibited a similar expression level of BGN as control mice, while FMOD was increased on day 3 after injury. These results indicate that DCN, in addition to its effects on fibrillogenesis, plays a regulatory role in angiogenesis and that FMOD in endothelial cells may be able to partially substitute for DCN. Copyright (C) 2004 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-BETA; ENDOTHELIAL-CELLS; EXTRACELLULAR-MATRIX; I COLLAGEN; DIFFERENTIAL EXPRESSION; TARGETED DISRUPTION; SKIN FRAGILITY; BIGLYCAN; PROTEOGLYCANS; FIBROMODULIN; inflammation; collagen; extracellular matrix; vascular endothelium; corneal epithelium |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 09:52 |
| Last Modified: | 04 Aug 2021 09:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38198 |
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