Kraemer, B. K. and Kammerl, M. C. and Komhoff, M. (2004) Renal cyclooxygenase-2 (Cox-2) - Physiological, pathophysiological, and clinical implications. KIDNEY & BLOOD PRESSURE RESEARCH, 27 (1). pp. 43-62. ISSN 1420-4096, 1423-0143
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Background/Aims: The role of COX-2 for renal function during renal development, for physiology and pathophysiology of renal diseases and the side effects of available COX-2 inhibitors, has gained increasing interest. We aimed therefore to review the respective role of renal COX-2. Methods: Review of relevant recent publications in the field, and in addition of in part unpublished data obtained in our laboratories. Results: COX-2 is 'constitutively' localized in the kidney i.e. in macula densa, TALH, interstitial cells, and is of utmost importance for normal renal development. Renal COX-2 is regulated by for example sodium and volume intake, angiotensin II, glucocorticoids often involving specific COX-2 promotor response elements. COX-2 derived prostanoids are required for preservation of renal blood flow and glomerular filtration especially in states of fluid deficit, they promote natriuresis, and furthermore may stimulate renin secretion during low-sodium intake/loop diuretic use. Conversely, COX-2 inhibitors decrease glomerular filtration, and renal perfusion, sometimes even causing acute renal failure. In addition, COX-2 inhibitors cause sodium retention, edema formation, cardiac failure and hypertension. The role of COX-2 derived prostanoids in renal inflammation or failure including diabetic nephropathy and renal transplantation remains at present controversial. Conclusion: COX-2 is one of the major players in renal physiology and pathophysiology. One focus of future work should be placed on COX-2 in primary renal diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONSTEROIDAL ANTIINFLAMMATORY DRUGS; VASCULAR ENDOTHELIAL-CELLS; RENIN-ANGIOTENSIN SYSTEM; CONGESTIVE-HEART-FAILURE; SYNDROME/ANTENATAL BARTTER-SYNDROME; ACUTE INTERSTITIAL NEPHRITIS; PASSIVE HEYMANN NEPHRITIS; MURINE LUPUS NEPHRITIS; NITRIC-OXIDE SYNTHASE; THICK ASCENDING LIMB; cyclooxygenase-2; acute renal failure; hypertension; edema; sodium retention; renin regulation; COX-2 inhibitors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie Biology, Preclinical Medicine > Institut für Physiologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 20 Jul 2021 09:08 |
| Last Modified: | 20 Jul 2021 09:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38200 |
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