Niller, Hans Helmut and Salamon, Daniel and Ilg, Karin and Koroknai, Anita and Banati, Ferenc and Schwarzmann, Fritz and Wolf, Hans and Minarovits, Janos (2004) EBV-associated neoplasms: alternative pathogenetic pathways. MEDICAL HYPOTHESES, 62 (3). pp. 387-391. ISSN 0306-9877
Full text not available from this repository. (Request a copy)Abstract
We propose that there are two main classes of Epstein-Barr virus (EBV) associated lymphomas: primarily malignant Burkitt's Lymphoma (BL) and Hodgkin's Disease (HD), on one hand, and primarily benign lymphoproliferations, e.g., post-transplant lymphoproliferative disease (PTLD) on the other hand. PTLD may start as a benign lymphoproliferation which becomes malignant if out of T cell control for too long. Our discovery of a binding site for the oncoprotein c-Myc at a central position of the EBV genome favours a distinction of pathogenetic pathways or scenarios for the proposed lymphoma classes. In the first scenario nuclear maintenance of the EBV genome and activation of viral anti-apoptotic functions with the help of c-Myc are indispensable for the origin of malignant tumours; (BL, HD) from the germinal centre B-cell. In the second scenario expression of the main viral transforming protein EBNA2 is essential for immortalisation and non-malignant morphological transformation of any (germinal centre derived or non-germinal centre) B-cell in the absence of T cell control. Although EBNA2 expression is permissible, under specific circumstances, in malignant B-cells, it is not required for oncogenesis. (C) 2003 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPSTEIN-BARR-VIRUS; INFECTED B-CELLS; HODGKINS-DISEASE; BURKITTS-LYMPHOMA; NUCLEAR MATRIX; DELETION; EXPRESSION; REGION; ONCOGENESIS; PATTERNS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 10:22 |
| Last Modified: | 04 Aug 2021 10:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38214 |
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