Cernovska, Katerina and Kemter, Miriam and Gallmeier, Hans-Christoph and Rzepecki, Petra and Schrader, Thomas and Koenig, Burkhard (2004) PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity. ORGANIC & BIOMOLECULAR CHEMISTRY, 2 (11). pp. 1603-1611. ISSN 1477-0520, 1477-0539
Full text not available from this repository. (Request a copy)Abstract
Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UNNATURAL AMINO-ACID; HETEROAROMATIC OLIGOAMIDES; ALZHEIMERS-DISEASE; STABILIZATION; AMINOPYRAZOLES; PROTONATION; MODELS; DNA; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jul 2021 07:58 |
| Last Modified: | 27 Jul 2021 07:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38233 |
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