Zaak, D. and Sroka, R. and Stocker, S. and Bise, K. and Lein, M. and Hoppner, M. and Frimberger, D. and Schneede, P. and Reich, O. and Kriegmair, M. and Knuechel, Ruth and Baumgartner, R. and Hofstetter, A. (2004) Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - In vivo experiments on the dunning rat tumor model. UROLOGIA INTERNATIONALIS, 72 (3). pp. 196-202. ISSN 0042-1138
Full text not available from this repository. (Request a copy)Abstract
Objective: In order to expand the use of photodynamic therapy (PDT) in the treatment of prostate carcinoma (PCA), the aim of this study was to evaluate PDT by means of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX ( PPIX) in an in vivo tumor model. Methods: The model used was the Dunning R3327 tumor. First of all, the pharmacokinetics and the localization of PPIX were obtained using fluorescence measurement techniques. Thereafter, PDT using 150 mg 5-ALA/kg b.w.i.v. was performed by homogenous irradiation of the photosensitized tumor (diode laser lambda = 633 nm). The tumors necrosis was determined histopathologically. Results: The kinetics of PPIX fluorescence revealed a maximum intensity in the tumor tissue within 3 and 4.5 h post-application of 5-ALA. At this time, specific PPIX fluorescence could be localized selectively in the tumor cells. The PDT-induced necrosis (n = 18) was determined to be 94 B 12% (range 60-100%), while the necrosis of the controls ( n = 12) differs significantly (p < 0.01), being less than 10%. Conclusion: These first in vivo results demonstrate the effective potential of 5-ALA-mediated PDT on PCA in an animal model. Copyright (C) 2004 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-LINES; PRINCIPLES; APOPTOSIS; CARCINOMA; LIGHT; photodynamic therapy; prostate cancer; 5-aminolevulinic acid |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2021 06:35 |
| Last Modified: | 10 Aug 2021 06:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38285 |
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