Treeck, O. and Diedrich, K. and Ortmann, Olaf (2003) Interaction between cellular estradiol response and receptor tyrosine kinase signaling: Implications for breast cancer therapy. GEBURTSHILFE UND FRAUENHEILKUNDE, 63 (12). pp. 1225-1232. ISSN 0016-5751, 1438-8804
Full text not available from this repository.Abstract
Growth of breast cancer cells is regulated by estrogens and growth factors. Cellular response to these stimuli is mediated by estrogen receptors and receptor tyrosine kinases. Originally both pathways were considered as independent signaling mechanisms. Now there is evidence for a broad cross-talk between these signal transduction pathways. The relationship between overexpression of HER-2/neu receptor tyrosine kinase and tamoxifen resistance is a possible example for the clinical relevance of this signaling cross-talk. Additionally, nongenomic effects of estrogens are able to interfere with the action of antitumoral substances directed against dysregulated receptor tyrosine kinases by activation of kinases downstream the receptor. Novel insights into the molecular mechanisms underlying the cross-talk between both signaling mechanisms and their impact on the efficacy of antitumoral substances directed against these pathways are reviewed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR RECEPTOR; ACTIVATED PROTEIN-KINASE; INSULIN-LIKE-GROWTH; LIGAND-INDEPENDENT RECRUITMENT; ESTROGEN-INDUCED ACTIVATION; CYCLIN D1; TAMOXIFEN RESISTANCE; ENDOCRINE THERAPY; CROSS-TALK; IN-VIVO; estrogens; estrogen receptor; growth factor; receptor tyrosine kinases; antiestrogens |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Jul 2021 07:39 |
| Last Modified: | 13 Jul 2021 07:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38346 |
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