May, Arne (2003) The trigeminovascular system in man: cerebral blood flow, functional imaging, and primary headache. NERVENARZT, 74 (12). pp. 1067-1077. ISSN 0028-2804, 1433-0407
Full text not available from this repository. (Request a copy)Abstract
Primary headache syndromes, such as cluster and migraine, are widely described as vascular headaches, even though there is considerable clinical evidence to suggest that both conditions are primarily central, that is regulated by the brain. The shared anatomical and physiological substrate for both clinical syndromes is the neural innervation of the cranial circulation. Early functional imaging using PET has shed light on the genesis of both syndromes, documenting activation in the midbrain and pons in migraine and in the hypothalamic gray in cluster headache. These areas are involved in the pain process in a permissive or triggering manner rather than simply as a response to first-division nociceptive pain impulses. This article reviews findings in the physiology of the trigeminovascular system which demand renewed consideration of the neural influences in many primary headaches and the physiology of the neural innervation of cranial circulation. Primary headaches should thus be regarded as neurovascular headaches to emphasize the interaction between nerves and vessels which is their underlying characteristic.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-RELATED PEPTIDE; POSITRON EMISSION TOMOGRAPHY; HYPOTHALAMIC GRAY-MATTER; BRAIN-STEM ACTIVATION; CLUSTER HEADACHE; ORBITAL PHLEBOGRAPHY; MIGRAINE AURA; SPREADING DEPRESSION; TRIGEMINAL GANGLION; VENOUS VASCULITIS; functional imaging; neurovascular headache; primary headache syndrome; trigeminovascular system; vascular headache |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 13 Jul 2021 07:57 |
| Last Modified: | 13 Jul 2021 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38376 |
Actions (login required)
 |
View Item |
