LC-NMR and LC-MS analysis of 2,3,10,11-oxygenated protoberberine metabolites in Corydalis cell cultures

Iwasa, Kinuko and Kuribayashi, Ayako and Sugiura, Makiko and Moriyasu, Masataka and Lee, Dong-Ung and Wiegrebe, Wolfgang (2003) LC-NMR and LC-MS analysis of 2,3,10,11-oxygenated protoberberine metabolites in Corydalis cell cultures. PHYTOCHEMISTRY, 64 (7). pp. 1229-1238. ISSN 0031-9422

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Abstract

The metabolism of 2,3, 10,1 I-oxygenated protoberberine alkaloids was studied in cell cultures of Corydalis species. Without prior isolation, the structures of the metabolites were determined by LC-MS and LC-NMR analyses. Tetrahydropseudocoptisine alpha-N-metho salt, pseudoprotopine, and pseudomuramine were identified for the first time, and preliminary evidence for metabolic pathways to the formation of these alkaloids were obtained. (C) 2003 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: ALKALOIDS; Corydalis platycarpa; Corydalis ochotensis var. raddeana; Fumariaceae; cell cultures; biotransformation; LC-MS; LC-NMR; secondary metabolism; protoberberine alkaloids
Subjects: 600 Technology > 615 Pharmacy
Divisions: Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 25 Aug 2021 09:24
Last Modified: 25 Aug 2021 09:24
URI: https://pred.uni-regensburg.de/id/eprint/38382

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