Piso, Pompiliu and Aselmann, H. and von Wasielewski, R. and Dahlke, M. H. and Klempnauer, J. and Schlitt, Hans J. (2003) Prevention of peritoneal carcinomatosis from human gastric cancer cells by adjuvant-type intraperitoneal immunotherapy in a SCID mouse model. EUROPEAN SURGICAL RESEARCH, 35 (6). pp. 470-476. ISSN 0014-312X
Full text not available from this repository. (Request a copy)Abstract
Purpose: We analyzed the effect of intraperitoneal immunotherapy in an animal model mimicking locoregional dissemination of tumor cells during resection of advanced tumors. Methods: We first established a tumor model with human gastric cancer cells (MKN-45) in the peritoneal cavity of CB-17-SCID mice. Three hours following the injection of tumor cells into the peritoneal cavity, mAb 17-1A alone and in combination with human LAK cells were given intraperitoneally at different dosages. The results were quantified by determining the weight of the peritoneal tumor masses. Results: After intraperitoneal administration of 17-1A mAb, a tumor reduction could be shown (median tumor mass after 10 mug mAb: 171 mug; after 100 mug: 130 mug) when compared with the control group (632 mug). Following a combined therapy with mAb and LAK cells, a statistically significant tumor reduction could be observed (after 10 mug mAb + 20-50 x 10(6) LAK cells: 80 mug; after 100 mug mAb + 20-50 x 10(6) LAK cells: 12 mug, p = 0.0005). With specific dosages of antibody and LAK cells it was even possible to achieve complete tumor clearance. Conclusions: Intraperitoneal immunotherapy reduces the peritoneal tumor masses and can even prevent the peritoneal carcinomatosis formation. Copyright (C) 2003 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MONOCLONAL-ANTIBODY; ANTITUMOR-ACTIVITY; OVARIAN-CANCER; THERAPY; CHEMOTHERAPY; COMBINATION; CYTOLOGY; peritoneal carcinomatosis; immunotherapy; SCID mouse |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2021 05:42 |
| Last Modified: | 30 Aug 2021 08:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38441 |
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