Ernst, W. (2016) Humanized mice in infectious diseases. COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 49. pp. 29-38. ISSN 0147-9571, 1878-1667
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The pathogenesis of infectious agents with human tropism can only be properly studied in an in vivo model featuring human cells or tissue. Humanized mice represent a small animal model featuring human cells or tissue that can be infected by human-specific viruses, bacteria, and parasites and also providing a functional human immune system. This makes the analysis of a human immune response to infection possible and allows for preclinical testing of new vaccines and therapeutic agents. Results of various studies using humanized mice to investigate pathogens with human tropism are presented in this review. In addition, the limitations of humanized mice and methods to improve this valuable animal model are discussed. (C) 2016 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMATOPOIETIC STEM-CELLS; DENGUE VIRUS-INFECTION; SCID IL2R-GAMMA(NULL) MICE; RESTRICTED IMMUNE-RESPONSES; SALMONELLA-TYPHI INFECTION; RAG-HU MICE; MOUSE MODEL; BLT MICE; T-CELLS; HIV-1 INFECTION; Review; Humanized mice; Infectious diseases; Human specific pathogens |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 Aug 2020 12:11 |
| Last Modified: | 27 Aug 2020 12:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3846 |
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