Klebl, Frank H. and Bregenzer, Nicole and Rogler, Gerhard and Straub, Rainer H. and Schoelmerich, Juergen and Andus, T. (2003) Treatment of pouchitis with dehydroepiandrosterone (DHEA) - a case report. ZEITSCHRIFT FUR GASTROENTEROLOGIE, 41 (11). pp. 1087-1090. ISSN 0044-2771, 1439-7803
Full text not available from this repository. (Request a copy)Abstract
Background: Dehydroepiandrosterone (DHEA) inhibits activation of nuclear factor kappa B (NF-kappaB), which is known to be activated in inflammatory lesions of ulcerative colitis, via PPARalpha. In a pilot trial DHEA was effective for the treatment of active ulcerative colitis. Pouchitis is a common complication after proctocolectomy for ulcerative colitis and still a therapeutical challenge. Case: DHEA 200 mg/d was tested in chronic active pouchitis in a 35-year-old female patient. DHEA was given for eight weeks, and follow up for further eight weeks was performed. The number of stools dropped from 15-18/d to 8/d, the addition of mucus, which was observed initially, was absent during treatment. The consistence of stools improved from liquid/soft to soft/solid. Abdominal pain resolved and endoscopical signs of inflammation improved. Eight weeks after termination of treatment with DHEA, the patient again suffered from 12 to 18 soft to liquid stools per day and mild abdominal pain. Conclusion: Therapeutic effects of DHEA in pouchitis should be evaluated systematically.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS; PLACEBO-CONTROLLED TRIAL; ULCERATIVE-COLITIS; DOUBLE-BLIND; DISEASE; METRONIDAZOLE; CIPROFLOXACIN; WOMEN; pouchitis; dehydroepiandrosterone; ulcerative colitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2021 07:21 |
| Last Modified: | 30 Aug 2021 07:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38500 |
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