Miehlke, Stephan and Schneider-Brachert, W. and Baestlein, E. and Ebert, S. and Kirsch, C. and Haferland, C. and Buchner, M. and Neumeyer, M. and Vieth, M. and Stolte, M. and Lehn, N. and Bayerdoerffer, E. (2003) Esomeprazole-based one-week triple therapy with clarithromycin and metronidazole is effective in eradicating Helicobacter pylori in the absence of antimicrobial resistance. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 18 (8). pp. 799-804. ISSN 0269-2813, 1365-2036
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Aim: This study aimed to investigate the effectiveness of a one-week triple therapy with esomeprazole, clarithromycin and metronidazole for eradication of Helicobacter pylori infection in the absence of antimicrobial resistance. Methods: Patients testing positive for H. pylori susceptible to metronidazole and clarithromycin (E-test) were randomized to receive a one-week regimen with either esomeprazole 2 x 20 mg or omeprazole 2 x 20 mg in combination with clarithromycin 2 x 250 mg and metronidazole 2 x 400 mg. Follow-up endoscopy with histology and culture and/or rapid urease test was performed 4-8 weeks after the end of treatment. Results: Eighty patients were randomized. Helicobacter pylori infection was cured in 38/39 patients of the esomeprazole group and 31/33 patients of the omeprazole group (per protocol 97.4% (95% confidence interval [CI], 86.2-99.9), 93.7% (95% CI, 79.2-99.2), P = 0.59); intention-to-treat 90.4% (95% CI: 77.4-97.3), 81.6% (95% CI: 65.7-92.3), respectively. No major side effects occurred. Minor side effects occurred in eight (20%) and six (23%) patients during esomeprazole and omeprazole therapy, respectively. Post-treatment susceptibility testing revealed resistance to both metronidazole and clarithromycin in two of the three patients who failed. Conclusion: We conclude that esomeprazole, clarithromycin and metronidazole as one-week triple therapy is effective for eradication of H. pylori in the absence of antimicrobial resistance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTIBIOTIC-RESISTANCE; MULTICENTER TRIAL; ACID CONTROL; SUSCEPTIBILITY; INFECTION; PROVIDES; METAANALYSIS; OMEPRAZOLE; REGIMENS; EFFICACY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 10:11 |
| Last Modified: | 04 Aug 2021 10:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38513 |
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