Gleich, Otto and Hamann, Ingo and Klump, G. M. and Kittel, Malte C. and Strutz, Juergen (2003) Boosting GABA improves impaired auditory temporal resolution in the gerbil. NEUROREPORT, 14 (14). pp. 1877-1880. ISSN 0959-4965
Full text not available from this repository.Abstract
Elderly humans often not only experience peripheral hearing loss but also suffer from more central deficits in temporal auditory processing affecting speech perception. Impaired auditory temporal resolution has also been observed in old rodents. Other studies have demonstrated a reduction of GABAergic function in the auditory pathway of old animals. Here we test the hypothesis that deficits in the GABAergic system affect central auditory processing. Our data suggests that pharmacological augmentation of the GABAergic system ameliorates impaired temporal auditory processing in the gerbil and might be a strategy for the treatment of at least some forms of central hearing loss in humans.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GAP DETECTION; MERIONES-UNGUICULATUS; INFERIOR COLLICULUS; COCHLEAR NUCLEUS; AGE; RECOGNITION; PRESBYCUSIS; ACUITY; LEVEL; MOUSE; aging; auditory pathways; auditory perception; auditory processing disorder; GABA agonists; presbycusis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2021 07:31 |
| Last Modified: | 30 Aug 2021 07:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38523 |
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