Schroeder, Ulrike and Kuehler, Andreas and Lange, Klaus W. and Haslinger, Bernhard and Tronnier, Volker M. and Krause, Martin and Pfister, Robert and Boecker, Henning and Ceballos-Baumann, Andres O. (2003) Subthalamic nucleus stimulation affects a frontotemporal network: A PET study. ANNALS OF NEUROLOGY, 54 (4). pp. 445-450. ISSN 0364-5134
Full text not available from this repository. (Request a copy)Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an effective strategy in the treatment of motor symptoms in advanced Parkinson's disease. However, clinical studies have shown that DBS can affect verbal fluency. Seven Parkinson's disease patients with bilateral DBS of the STN were studied with positron emission tomography (PET) to investigate the effects of STN stimulation on regional cerebral blood flow during a verbal fluency task. Activation of the right orbitofrontal cortex and verbal fluency-associated activation within a left-sided frontotemporal network were decreased during STN stimulation compared with the OFF state. Our results offer an explanation for the commonest neuropsychological side effect of STN stimulation and show that STN stimulation affects a frontotemporal network during a fluency task.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEEP-BRAIN-STIMULATION; CHRONIC BILATERAL STIMULATION; PARKINSONS-DISEASE; BASAL GANGLIA; PREFRONTAL CORTEX; WORD COMPREHENSION; FUNCTIONAL-ANATOMY; COGNITIVE FUNCTION; GLOBUS-PALLIDUS; VERBAL FLUENCY; |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2021 08:34 |
| Last Modified: | 30 Aug 2021 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38531 |
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