Jeron, Andreas and Kaiser, Tanja and Hengstenberg, Christian and Loewel, Hannelore and Riegger, Günter A. J. and Holmer, Stephan (2003) Association of the heart rate turbulence with classic risk stratification parameters in postmyocardial infarction patients. ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, 8 (4). pp. 296-301. ISSN 1082-720X
Full text not available from this repository.Abstract
The heart rate turbulence (HRT) parameters were introduced for risk stratification of ventricular arrhythmias in postmyocardial infarction patients. However, the relationship of these parameters with other risk stratificators such as heart rate variability (HRV), repolarization parameters or left ventricular function is unknown. Furthermore, the influence of age and medication on HRT remains to be evaluated. Holter ECG's of 509 post-MI patients (1-10 years after MI) were screened for single ventricular extrasystole. In 196 patients the parameters' turbulence onset (TO) and turbulence slope (TS) could be computed. A pathological TO (>0%) and TS (<2.5 ms) was found in 58 and 54 patients, respectively. HRT was not related to gender, but was correlated with age (TS: r = 0.209, P < 0.01). No relationship was observed between QT interval, QTc interval or QT dispersion and HRT parameters. Individuals with a pathological HRT showed decreased HRV values (e.g., PNN50: 2.8 vs. 11.5; P < 0.001). Of all MI patients with systolic left ventricular dysfunction (EF < 45%, n = 46), 18 showed a pathological TO (39%) compared to 34 out of 142 patients (24%) with an EF > 45%. In contrast, the percentage of pathological HRT was not different between patients with left ventricular hypertrophy (16 out of 59, 27%) compared to patients without LVH (38 out of 133, 28%). The HRT was pathological in 14 out of 24 patients with diabetes mellitus (58%) compared to 40 out of 172 (23%) normoglycemic patients (TO: -0.6 +/- 3.1 vs. -2.5 +/- 5.5, P < 0.02). HRT was similar in patients with beta-blockers (n = 96) as in patients without beta-blockers (n = 100). In stable post-MI patients, HRT is influenced by age and left ventricular function and correlates with heart rate variability. Therapy with beta-blockers has no influence on HRT, while diabetic patients may have an increased likelihood of pathological HRT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYOCARDIAL-INFARCTION; PROGRAMMED VENTRICULAR STIMULATION; HOSPITAL CARDIAC-ARREST; T-WAVE ALTERNANS; RATE-VARIABILITY; EJECTION FRACTION; BAROREFLEX SENSITIVITY; ARRHYTHMIC EVENTS; SUDDEN-DEATH; SHORT-TERM; heart rate turbulence; risk stratification; myocardial infarction; diabetes mellitus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 10:19 |
| Last Modified: | 04 Aug 2021 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38532 |
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