Willer, Tobias and Valero, M. C. and Tanner, Widmar and Cruces, J. and Strahl, Sabine (2003) O-mannosyl glycans: from yeast to novel associations with human disease. CURRENT OPINION IN STRUCTURAL BIOLOGY, 13 (5). pp. 621-630. ISSN 0959-440X, 1879-033X
Full text not available from this repository.Abstract
In yeasts and other fungi, O-mannosyl glycans constitute a major protein modification that is essential for cell viability. For several decades, protein O-mannosylation was considered a yeast-specific modification. Thus, it was especially interesting when it became evident that O-mannosyl glycans in mammals are not as rare as previously thought. O-mannosyl glycans are abundant in the mammalian brain and are also an abundant modification of of alpha-dystroglycan, a component of the dystrophin-glycoprotein complex. Recently, mutations in genes that are or might be involved in the glycosylation of alpha-dystroglycan have been identified. Their association with neuromuscular diseases has focused the attention of different research areas on protein O-mannosylation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONGENITAL MUSCULAR-DYSTROPHY; WALKER-WARBURG-SYNDROME; FUKUTIN-RELATED PROTEIN; REDUCTIVE ALKALINE-HYDROLYSIS; EYE-BRAIN DISEASE; ENDOPLASMIC-RETICULUM; SACCHAROMYCES-CEREVISIAE; ALPHA-DYSTROGLYCAN; ALPHA-3-D-MANNOSIDE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE-I; SKELETAL-MUSCLE; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Lehrstuhl für Zellbiologie und Pflanzenphysiologie (Prof. Dr. Klaus Grasser) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 Jul 2021 09:20 |
| Last Modified: | 08 Jul 2021 09:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38541 |
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