Bataille, Frauke and Klebl, Frank and Ruemmele, Petra and Straub, Rainer H. and Wild, Peter and Schoelmerich, Juergen and Hofstaedter, Ferdinand (2003) Histopathological parameters as predictors for the course of Crohn's disease. VIRCHOWS ARCHIV, 443 (4). pp. 501-507. ISSN 0945-6317, 1432-2307
Full text not available from this repository. (Request a copy)Abstract
Background. Recent classification systems discriminate penetrating Crohn's disease (CD) from stricturing and non-stricturing/non-penetrating CD. As yet, no easily detectable marker is known that can predict the course of CD. Individual, clinical course-specific new treatment schemes would be highly desirable for different potentially divergent pathophysiological pathways (e.g., fistula vs stenosis). Methods. Intestinal tissue biopsies from 63 CD patients with a disease follow-up of up to 7 years were studied retrospectively. In biopsy specimens, 34 histopathological features present prior to the onset of (a) strictures or (b) fistulas were evaluated and compared with biopsies from patients with non-stricturing/non-penetrating disease. Results. Five histomorphological parameters demonstrated significant associations to different disease courses when applying univariate analysis. In a multivariate logistic regression model (1) severe lymphocytic infiltration of the lamina propria, (2) presence of crypt atrophy, and (3) absence of lymphocytic infiltration of the epithelium are the best variables to predict an uncomplicated disease course (Nagelkerke R2=0.329; P=0.001). The combination of these parameters has a sensitivity of 67% and a specificity of 83% to predict non-stricturing/non-penetrating disease (positive predictive value=0.75). Conclusion. Histopathological parameters may help to predict complications of CD prior to their onset. The results of this study have to be confirmed prospectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; INTESTINAL PERMEABILITY; ULCERATIVE-COLITIS; BIOPSY SPECIMENS; RELAPSE; CLASSIFICATION; CALPROTECTIN; PHENOTYPE; MARKERS; PROTEIN; Crohn's disease; histological feature; disease behavior |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2021 13:08 |
| Last Modified: | 30 Aug 2021 13:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38588 |
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