Buechler, Christa and Ullrich, Heidrun and Aslanidis, Charalampos and Bared, Salim Maa and Lingenhel, Arno and Ritter, Mirko and Schmitz, Gerd (2003) Lipoprotein (a) downregulates lysosomal acid lipase and induces interleukin-6 in human blood monocytes. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1642 (1-2). pp. 25-31. ISSN 0167-4889
Full text not available from this repository. (Request a copy)Abstract
The association of elevated lipoprotein (a) (Lp(a)) with an increased risk for coronary events is clearly established. This increased risk may in part be due to the activation of monocytes as major cells involved in atherogenesis. High concentrations of plasma Lp(a) were shown to influence the gene expression of human blood monocytes and in the present study we demonstrate a reduced abundance of the lysosomal acid lipase (LAL) mRNA in monocytes of patients with coronary disease and selective Lp(a) hyperlipidemia. This is also supported by in vitro studies where purified Lp(a) but not low-density lipoprotein (LDL) was shown to downregulate mRNA levels of the LAL in control monocytes. A correlation of Lp(a) serum levels and the proinflammatory cytokine IL-6 was recently also described. Therefore, we investigated whether Lp(a) is capable to enhance the release of this acute phase cytokine from human blood monocytes. Purified Lp(a) led to an increased secretion of IL-6, but not TNF-alpha arguing against a general activation of these cells. The association of reduced LAL activity with the premature development of coronary artery disease has been demonstrated in patients with hypercholesterolemia, and in the present study we show for the first time that LAL expression is suppressed in monocytes from patients with Lp(a) hyperlipidernia and by purified Lp(a). In addition, increased levels of IL-6 also predict future cardiovascular events and IL-6 secretion was also induced by purified Lp(a). (C) 2003 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-HEART-DISEASE; CHOLESTERYL ESTER; PLASMINOGEN; EXPRESSION; HYPERCHOLESTEROLEMIA; APOLIPOPROTEIN(A); ATHEROSCLEROSIS; MECHANISM; LP(A); RISK; lipoprotein (a); lysosomal acid lipase; interleukin-6; blood monocyte; atherogenesis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Jul 2021 09:53 |
| Last Modified: | 29 Jul 2021 09:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38597 |
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