Kreuzer, M. and Heinrich, J. and Wolke, G. and Rosario, A. S. and Gerken, Michael and Wellmann, J. and Keller, G. and Kreienbrock, L. and Wichmann, H. E. (2003) Residential radon and risk of lung cancer in Eastern Germany. EPIDEMIOLOGY, 14 (5). pp. 559-568. ISSN 1044-3983
Full text not available from this repository.Abstract
Background: There is suggestive evidence that residential radon increases lung cancer risk. To elucidate this association further, we conducted a case-control study in Thuringia and Saxony in Eastern Germany during 1990-1997. Methods: Histologically confirmed lung cancer patients from hospitals and a random sample of population controls matched on age, sex and geographical area were personally interviewed with respect to residential history, smoking, and other risk factors. One-year radon measurements were performed in houses occupied during the 5-35 years prior to the interview. The final analysis included a total of 1,192 cases and 1,640 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression. Results: Measurements covered on average 72% of the exposure time window, with mean radon concentrations of 76 Bq/m(3) among the cases and 74 Bq/m(3) among the controls. The smoking- and asbestos-adjusted ORs for categories of radon (50-80, 80-140 and > 140 Bq/m(3), compared with 0-50 Bq/m(3)) were 0.95 (CI = 0.77 to 1.18), 1.13 (CI = 0.86 to 1.50) and 1.30 (CI 0.88 to 1.93). The excess relative risk per 100 Bq/ml was 0.08 (CI -0.03 to 0.20) for all subjects and 0.09 (CI = -0.06 to 0.27) for subjects with complete measurements for all 30 years. Conclusions: Our data indicate a small increase in lung cancer risk as a result of residential radon that is consistent with the findings of previous indoor radon and miner studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPOSURE ASSESSMENT; MEASUREMENT ERROR; URANIUM MINERS; WOMEN; SWEDEN; DETECTORS; MODELS; case-control study; lung neoplasm; radon; tobacco smoke |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2021 09:42 |
| Last Modified: | 30 Aug 2021 09:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38650 |
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